Cleopatra III. was the daughter of Ptolemy VI. and Cleopatra II. and wife of Ptolemy VIII. With Ptolemy VIII. she had five children:
- Ptolemy IX
- Cleopatra VI
- Ptolemy X. Alexander I.
- Cleopatra Selene
Cleopatra III. ruled togehter with her husband and mother and later with her sons – Ptolemy IX and Ptolemy X. She was the most important person at Alexander's court. She ruled after the death of Ptolemy VIII since September 101 BC till she was murdered at Ptolemy X command.
Wall relief of Cleopatra III., Cleopatra II. and Ptolemy VIII. before Horus