Hatshepsut was the only Queen, who seized the throne and let depicted herself as a man. She was the first-born daughter of Thutmose I. and the Queen Ahmose and she was already interested in royal affairs since her childhood. This interest grew even stronger after wedding with her half-brother Thutmose II. Then she took the guardianship over her step-son nephew - little Thutmose III. after death of Thutmose II.
Hatshepsut - Woman depicting the pharaoh as a (male)
Even if Hatshepsut appointed a title of co-ruler to her step-son, she cared about the state administration all alone. Her reign lasted for 22 years (approximately 1,504 - 1,482 BC) and she stimulated business and sciences flourishing during her reign. Hatshepsut organized a campaign into the mysterious Land of Punt that was likely situated on the Red Sea shore in Arabia or on the eastern shore of Africa. The Egyptians imported olibanum and perfumes from there that were used for gods worshipping.
Temple of Hatshepsut at Deir el-Bahri
Hatshepsut tried to continue in tradition of significant periods and she let erect two granite obelisks from a single piece of stone in Karnak, which were taller than all obelisks before. But the main building work of the Queen Hatshepsut was her own sanctuary and a chantry temple in Deir el-Bahari. The temple in Deir el-Bahari is "sticked" to a massif and partly embedded right into the rock. It extended on three terraces that lean against walls, colonnades standing on sides and they are connected together with a main ascending ramp. This unique building is work of the most inventive architect in ancient Egypt - Senenmut.
The anger of Thutmose III continually grew and he decided to destroy everything what could seemingly remind his step-mother and aunt Hatshepsut when he came to the throne. He erased her name out of royal documents, defaced statues of her, let hew away her depictions and names of her favourites as well. Also Senenmut became an object of his vengeance.